What is the immunophenotype typically associated with Hodgkin's lymphoma?

Hodgkin's lymphoma is characterized by the presence of Reed-Sternberg cells, which are crucial for its diagnosis. The definitive immunophenotype associated with this type of lymphoma is marked by the expression of CD15 and CD30. These cell surface markers indicate the presence of these atypical cells and help differentiate Hodgkin's lymphoma from other lymphomas.

CD15 is a carbohydrate antigen found on Reed-Sternberg cells, while CD30 is a member of the tumor necrosis factor receptor superfamily and is also commonly expressed in these cells. The presence of both markers is integral to the diagnosis and classification of Hodgkin's lymphoma.

Other markers listed in the options, such as CD4 and CD8, primarily relate to T-cell activation and differentiation and are not specifically associated with Hodgkin's lymphoma. Similarly, CD19 and CD22 are typical B-cell markers, which are not characteristic of Reed-Sternberg cells in Hodgkin's lymphoma. CD45 is a common leukocyte marker; however, the negativity for CD45 is not diagnostic for Hodgkin's lymphoma as other lymphoid neoplasms may still express this antigen.

Thus, the positivity for CD15 and CD30 is the hallmark immunophenotype of Hodgkin's lymphoma,