What is the primary histological feature of a high-grade glioma?

The primary histological feature of a high-grade glioma is abundant pleomorphic nuclei and necrosis. High-grade gliomas, which include glioblastomas, are characterized by their aggressive nature and significant cellular variation. The presence of pleomorphic nuclei indicates a high degree of cellular atypia, meaning that the tumor cells vary in shape and size, reflecting their malignant transformation.

Necrosis is also a hallmark of high-grade gliomas, often noted within the tumor tissue. This occurs due to rapid cellular proliferation exceeding the blood supply, resulting in cell death. The combination of nuclear pleomorphism and necrosis not only signifies the tumor's high grade but also correlates with a poorer prognosis for patients. Consequently, the distinctive histological features of pleomorphic nuclei and areas of necrosis are critical for identifying and classifying high-grade gliomas. This aids in determining the most appropriate management strategies for affected patients.