Which feature helps distinguish neuroendocrine tumors from other neoplasms?

Neuroendocrine tumors are characterized by their ability to produce and secrete hormones and other neuroactive substances. A key feature that helps distinguish these tumors from other neoplasms is the presence of neurosecretory granules. These granules are specialized cellular structures found in neuroendocrine cells, which are derived from the neuroectoderm and show both endocrine and neuronal characteristics. Upon examination using electron microscopy or specific staining techniques, these granules can be visualized, confirming the neuroendocrine nature of the tumor.

The presence of neurosecretory granules is a distinguishing characteristic not typically found in non-neuroendocrine tumors, making this feature essential for accurate diagnosis and pathology. Recognizing these granules can guide further clinical management and therapeutic options for patients with neuroendocrine tumors.